Sodium-induced cardiac hypertrophy. Cardiac sympathetic activity versus volume load.
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چکیده
منابع مشابه
Sodium-induced cardiac hypertrophy. Cardiac sympathetic activity versus volume load.
To investigate the possible contributions of cardiac volume overload and cardiac sympathetic hyperactivity in the effects of sodium on cardiac mass, we evaluated the effects of treatment with saline (1%) and deoxycorticosterone acetate + saline (DOCA/saline) for 10 days and 3 and 6 weeks on ventricular anatomy and intracardiac pressures. Sympathetic activity in the heart and other tissues was a...
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BACKGROUND Left ventricular (LV) hypertrophy is an independent risk factor for cardiovascular morbidity and mortality in hypertensive subjects. Sympathetic activation has been suggested to contribute to LV hypertrophy, but this has not yet been conclusively validated in humans. METHODS AND RESULTS We comprehensively assessed total systemic and regional sympathetic activity by radiotracer dilu...
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BACKGROUND Although inadequate intake of essential nutrient choline has been known to significantly increase cardiovascular risk, whether additional supplement of choline offering a protection against cardiac hypertrophy remain unstudied. METHODS The effects of choline supplements on pathological cardiac hypertrophic growth induced by transverse aorta constriction (TAC) for three weeks and ca...
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BACKGROUND Cardiac hypertrophy, or an increase in heart size, is an important risk factor for cardiac morbidity and mortality. The mammalian target of rapamycin (mTOR) is a component of the insulin-phosphoinositide 3-kinase pathway, which is known to play a critical role in the determination of cell, organ, and body size. METHODS AND RESULTS To examine the role of mTOR in load-induced cardiac...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1991
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.68.3.745